V-ICI Research topics: Laboratory of Immunogenetics

Oncogenesis: Cancer genetics

Genetic susceptibility, environmental factors, Helicobacter pylori infection, pre-malignant conditions and gastric cancer risk in the European population

J.B.A. Crusius1, S.A. Morré, S. Ouburg1,2, A. Lanas3, P.H. Savelkoul4, E. Bloemena3, E.C. Klinkenberg-Knol2,  C.J.J. Mulder2, A.S. Peña1,2

1Laboratory of Immunogenetics, 2Departments of Gastroenterology and 3Pathology, VU University Medical Center (5th FP of EC: The EUR-GAST, Euro 142.000. QLG1-CT-2001-01049) (MLDS Gastrostart Subsidie)

Mucosal infection (Helicobacter pylori and EBV) and chronic inflammation contributes to the development of gastric cancer. We are studying genetic susceptibility and environmental factors as an integrated model of gastric carcinogenesis. A large multi-centre prospective European cohort is being studied. The Laboratory of Immunogenetics contributes with large scale genotyping of cytokine gene polymorphisms. Other European Laboratories study the contribution of other genes involved in mucosa protection, oxidative damage, DNA repair, oncogenes and tumour suppressor genes.

Our research group also focuses on pre-malignant lesions such as peptic ulcer. We study clinical inflammation scores, the presence of H. pylori infection, predisposing bacterial factors, cag/vac status, and host gene polymorphisms in relation to susceptibility and severity of peptic ulcer.

Publications

(WI) Debets-Ossenkopp YJ, Reyes G, Mulder J, Aan de Stegge BM, Peters JT, Savelkoul PH, Tanca J, Peña AS, Vandenbroucke-Grauls CM. Characteristics of clinical Helicobacter pyloristrains from Ecuador. J Antimicrob Chemother 2003;51:141-5.

(WI) García-González, MA, Lanas A, Savelkoul PH, Santolaria S, Benito R, Crusius JBA, Peña AS. Association of interleukin 1 gene family polymorphisms with duodenal ulcer disease. Clin Exp Immunol 2003; 134(3): 525-31.

(WI) González, CA, Peña S, Capellá G. Clinical usefulness of virulence factors of Helicobacter pylori as predictors of the outcomes of infection. What is the evidence?  Scand J Gastroenterol 2003; 38(9): 905-15.

(WI) zur Hausen A, Crusius JBA, Murillo LS, Morré SA, Alizadeh BZ, Meijer CJML, van den Brule AJC, Peña AS. IL-1B promoter polymorphism and Epstein-Barr virus in Dutch patients with gastric carcinoma.  Int J Cancer 2003; 107 (5): 866-7.